ã¢ããé䌎ãŠã€ã«ã¹ãã¯ã¿ãŒãçšããŠç¹å®ã®ç¥çµçŽ°èã«çºçŸããã人工å容äœãšããã®äººå·¥å容äœã®ã¿ãç¹ç°çã«å¶åŸ¡ã§ããçµå£æäžå¯èœãªäœååååç©ãçšããç¬èªãã©ãããã©ãŒã ã§ãç¥çµå æ§çŒçããŠãããã®æ²»çæ³éçºãç®æããã€ãªãã³ãã£ãŒ
ããŒã ããŒãžïŒhttps://www.codabiotherapeutics.com/
èæ¯ãšãã¯ãããžãŒïŒ
ã»ã¢ã«ããã€ããŒç ãããŒãã³ãœã³ç ãçèçž®æ§åŽçŽ¢ç¡¬åçïŒALSïŒãªã©ã®ç¥çµå€æ§çŸæ£ã¯ãæ¿èªè¬ãå°ãªãããã®æ²»çæºè¶³åºŠãäœããçµ±å倱調çããã€ç ãªã©ã®ç²Ÿç¥çŸæ£ã¯è€æ°ã®æ²»çè¬ã¯ããããã»ãšãã©ãé¡äŒŒã®äœçšã¡ã«ããºã ã§ãããæ²»çæµææ§ãšãªãæ£è ãããå€ãçŸæ£ã§ããããã®ããã«äžæ¢ç¥çµç³»çŸæ£ã«ã¯ã¢ã³ã¡ããã¡ãã£ã«ã«ããŒãºã®é«ãçŸæ£ãå€ãã
ã»äžæ¢ç¥çµç³»çŸæ£ã®ã¢ã³ã¡ããã¡ãã£ã«ã«ããŒãºãé«ãã«ãé¢ããããæ²»çè¬ãå°ãªãçç±ãšããŠã¯ä»¥äžã®ãããªåå ãèããããŠããã
â çŸæ£ã®åå ãåµè¬ã¿ãŒã²ããååãäžæ
ç¥çµå€æ§çŸæ£ã粟ç¥çŸæ£ãšãçŸæ£ã®åå ã«ã€ããŠåãã£ãŠããªãããšãå€ããã¢ã«ããã€ããŒç ã¯ã¢ããã€ãβã®èç©ã«ãã£ãŠèµ·ãããšèããããŠããããæã¢ããã€ãβæäœãçšããŠè³å ã®ã¢ããã€ãβéãæžãããŠãèããèªç¥æ©èœæ¹åå¹æã¯çŸåšãŸã§ã®ãšããèŠãããŠããªãã粟ç¥çŸæ£ã¯ãã®çŸæ£åå ã«ã€ããŠãäžæãªç¹ãå€ãäžãæ°è¬ã®å€ãã¯ãå¶ç¶èŠã€ãã£ãã¢ãã¢ãã³ïŒãããã³ãã»ãããã³ããã«ã¢ãã¬ããªã³ïŒã·ã°ãã«ã調ç¯ããè¬ããã³ãã®é¡äŒŒè¬ã®ã¿ã§ããã
â¡ãã€ãªããŒã«ãŒã®äžåš
ç¥çµå€æ§çŸæ£ã粟ç¥çŸæ£ãšãäœããã®è³å ã®å€åã«ãã£ãŠèµ·ãã£ãŠãããšèããããŠãããããã®å€åãæãããããã€ãªããŒã«ãŒãèŠã€ãã£ãŠããªããã¢ã«ããã€ããŒç ã«ãããŠã¯ãè³å ã¢ããã€ãβéã枬å®ã§ããPETã€ã¡ãŒãžã³ã°ãéçºãããŠããããéåžžã«é«äŸ¡ãªããããŒãã«ãé«ãããŸãâ ã«ãèšèŒããããã«ã¢ããã€ãβãæžå°ãããŠãèªç¥æ©èœæ¹åãèŠãããªãããšãå ±åãããŠãããè¡äžãã€ãªããŒã«ãŒãšããŠã¯ãã¢ã«ããã€ããŒç ã§ãã¥ãŒããã£ã©ã¡ã³ã軜éã®éãå¢å ããå¯èœæ§ãå ±åãããŠãããããŸã 蚺æã«äœ¿çšã§ããã«ã¯è³ã£ãŠããªãã
â¢è¡æ¶²è³é¢éã®ååš
æ²»çä»å ¥ããæã«ããŒãã«ãšãªãã®ããè¡æ¶²è³é¢éã®ååšã§ãããè¡æ¶²äžããè³å ãžã®ç©è³ªã®ç§»åã¯å³å¯ã«ã³ã³ãããŒã«ãããŠãããã°ã«ã³ãŒã¹ãªã©éãããå°ååããè³å ã«å ¥ãããšãã§ããªãããã®ã³ã³ãããŒã«ãè¡ã£ãŠããã®ãè¡æ¶²è³é¢éã§ãããè¡æ¶²è³é¢éã®ããã«ãæäœãããã±ã質ãæ žé žãªã©ã®é«ååã¯è³å ã«å ¥ãããšãã§ããªããäœååååç©ã®è³ãžã®ééã«ã€ããŠãååéãè溶æ§ãªã©ã®å³ããæ¡ä»¶ãããäžãåãã£ãŠããªãããšãå€ãããã®ããæ²»çè¬ãäœãããŒãã«ãéåžžã«é«ãã
â£ç¥çµåè·¯ã調ç¯ããææ³ã®äžåš
è³ãæ©èœãçºæ®ããã¡ã«ããºã ã®äžã€ãšããŠãç¥çµçŽ°èå士ãåè·¯ã圢æãããã®åè·¯ãšããŠã®æŽ»åããæ©èœãçºæ®ãããŠãããšãã仮説ãããããããããããŸã§ã®åµè¬ã¯åµè¬ã¿ãŒã²ããååãèŠåºããããã«äœçšããååç©ãçšããã¢ãããŒããäž»ã ã£ãããã®ããè³æ³¢æž¬å®ãfMRIã€ã¡ãŒãžã³ã°ãªã©ã§ç¹å®ã®ç¥çµåè·¯ã調ç¯ããããšã§çŸæ£å¶åŸ¡ã§ããå¯èœæ§ã瀺ãããŠããŠãããããããã³ã³ãããŒã«ã§ããææ³ã確ç«ããŠããªãã
ã»â¢ãâ£ã®åé¡ã解決ããæ¹æ³ãšããŠæè¿ãTMSïŒTranscranial Magnetic StimulationïŒçµé èç£æ°åºæ¿æ³ïŒã«ãã粟ç¥çŸæ£æ²»çã泚ç®ãããŠãããããã¯ãé ç®äžã«çœ®ãããåºæ¿ã³ã€ã«ã«ããçæéã§å€§ããªé»å§ããããŠæ¥éïŒ100 ÎŒ sçšåºŠã®ç«ã¡äžããïŒã«é»æµãæµããŠå€åç£å Žãçºçããããå€åç£å Žã®åœ±é¿äžã«ãã倧è³ç®è³ªãã³ã³ãã³ãµã®ããã«æ¯ãèããåºæ¿ã³ã€ã«ã«æµããé»æµãšã¯éåãïŒç£å Žã®å€åãæã¡æ¶ãããšããæ¹åïŒã®èªå°é»æµïŒæžŠé»æµïŒãåºæ¿ã³ã€ã«ã®çŽäžã«çããŠãç¥çµçŽ°èãé»æ°åºæ¿ããŠæŽ»åé»äœãçãããšããã¡ã«ããºã ã§ç¥çµåè·¯ã調ç¯ããå»çæ©åšã§ãããå埩æ§ã®TMSïŒrTMSïŒã¯ç¥çµå¯å¡æ§ã亢é²ãåºæ¿çµäºåŸã«ãæç¶ããé·æå¹æãæã€ããã粟ç¥ç¥çµçŸæ£ã®æ²»çå¿çšç 究ããªãããŠããããã€ç ã«å¯ŸããrTMSã®æ²»çç䜿çšã¯1995幎以éçãã«ç 究ããã2008幎ã«ã¯ç±³åœFDAã®æ¿èªãåããŠããïŒåºå žPDFïŒã
ã»ä»å玹ä»ããCODA Biotherapeuticsã¯ãç¹å®ã®ç¥çµåè·¯ãå¶åŸ¡ããããã«éºäŒåæ²»çãšäœååååç©ãçµã¿åãããæ²»çæ³ïŒã±ã¢ãžã§ããã£ã¯ã¹ïŒã®éçºãè¡ã£ãŠãããã€ãªãã³ãã£ãŒã§ãããCODA BiotherapeuticsãéçºããŠããæè¡ãã©ãããã©ãŒã ã§ã¯ãéºäŒåæ²»çã«ãã£ãŠæšçãšãªãç¥çµçŽ°èãæ¹å€ãã調æŽå¯èœãªãªã¬ã³ãäŸååã€ãªã³ãã£ãã«ïŒäººå·¥å容äœïŒãçºçŸãããããã®ãªã¬ã³ãäŸååã€ãªã³ãã£ãã«ã¯ãç¬èªã«éçºããç¹å®ã®å°ååã«åŒ·ãåå¿ããããã«èšèšãããŠãããããã以å€ã¯äžæŽ»æ§ã§ãããæäžãããäœååååç©ãšäººå·¥å容äœã®çžäºäœçšã«ãããç¥çµçŽ°èãçšéäŸåçã«å¶åŸ¡ããæ²»çå¹æãåŸãããšãã§ãããšããæè¡ã§ããã
ã»å®éšåç©ãçšããéèšåºç 究æè¡ãšããŠã¯ç¢ºç«ãããŠãããDREADDs (designer receptors exclusively activated by designer drug)ãšåŒã°ããã人工å容äœã®äžäŸãšããŠã¯ãæ¹å€ãããM3ã ã¹ã«ãªã³æ§ã¢ã»ãã«ã³ãªã³å容äœãçšãããç¹ç°çãªå¶åŸ¡å€ãšããŠã®äœååååç©ã¯ãã¯ãã¶ãã³-N-ãªãã·ãïŒCNO)ãçšããããã人工å容äœã¯çäœå ã®ã¢ã»ãã«ã³ãªã³ã«ã¯åå¿ãããCNOã«ã®ã¿åå¿ãããCNOãè¬çåŠçã«äžæŽ»æ§ã§ããã
ã»CODA Biotherapeuticsç¬èªã®ãã©ãããã©ãŒã ã§ã¯ã人工å容äœã¯ãã¢ããé䌎ãŠã€ã«ã¹ïŒAAVïŒãã¯ã¿ãŒã«ãã£ãŠçºçŸããããAAVã®ãã£ãã·ããšããã¢ãŒã¿ãŒãéžæããããšã§ãè€æ°ã®ã¿ã€ãã®ç¥çµçŽ°èã®æŽ»æ§ã調ç¯ããããšãã§ããããã®çµæãåºç€çãªç æ ççãç°ãªãå€ãã®ç¥çµçŸæ£ã®æ²»çã«æè»ã«å¯Ÿå¿ããããšãã§ãããšCODA Biotherapeuticsã¯èšç»ããŠããã
ã»CODA Biotherapeuticsã¯ãè€æ°ã®äººå·¥å容äœããã³ãããç¹ç°çã«å¶åŸ¡ã§ããçµå£æäžå¯èœãªäœååååç©ãéçºããŠãããæšæºçãªè³å€ç§æè¡ãçšããŠãAAVãã¯ã¿ãŒãæšçãšãªãç¥çµçŽ°èã«çŽæ¥æäžããããšã§ãæšçå€ãžã®åœ±é¿ãæãããã¿ãŒã²ãããšãªãç¥çµçŽ°èã§çºçŸãã人工å容äœã¯ãäœååååç©ã«ãã£ãŠå¶åŸ¡ãããç¥çµçŽ°èã®æŽ»åã調ç¯ããããšãã§ãããããã«ãããè¬å€ã®æäžéã«å¿ããŠãå容äœãã²ããŠã¯ç¥çµçŽ°èã®æŽ»åãéžæçã調æŽçãå¯éçã«å¶åŸ¡ããããšãå¯èœãšãªãã
ãã€ãã©ã€ã³ïŒè©³çŽ°æªé瀺
ã»ç¥çµå æ§çŒç
çŸè¡æ²»çæ³ãšããŠãæ«æ¢¢ç¥çµãäžæ¢ç¥çµã®äžéšãåé€ããæè¡ãšããã¢ãããŒããããããæçµæ段ã§ãããåŸéºçãæ®ãå¯èœæ§ããããéçºã¹ããŒãžäžæã
ã»çŠç¹æ§ãŠããã
è³ã®ç¹å®ã®å ŽæïŒéåžžã¯çæ¹ã®åçïŒããçºäœãèµ·ããããŠãããå šäœã®çŽ60ïŒ ãå ãããå€ç§çæè¡ã¯ãè³ã®äžéšãåé€ãããããåŸéºçãæ®ãå¯èœæ§ããããéçºã¹ããŒãžäžæã
æè¿ã®ãã¥ãŒã¹ïŒ
CODA Biotherapeutics ã¯Attenuaãè²·åãããããã«ããPhase IIãå«ãè€æ°ã®èšåºè©Šéšã«ãããŠå®å šæ§ãšå¿å®¹æ§ã確èªãããŠãã3ã€ã®äœååååç©ãååŸãCODAã§ã¯ãã®äœååååç©ã«ãã£ãŠå¶åŸ¡ã§ãã人工å容äœãèšèšããã
ã³ã¡ã³ãïŒ
ã»ãã¶ã€ããŒå容äœããã¶ã€ããŒååç©ã§åºæ¿ããŠç¹å®ã®ç¥çµåè·¯ãå¶åŸ¡ãããšããæå
端æè¡ã®èšåºå¿çšãç®æããã€ãªãã³ãã£ãŒãéåžžã«é¢çœãæè¡ã ããçäœå
ã§ã¯å
šãåããªããæšçã®ãã¶ã€ããŒå容äœã«ã ãåãäœååãšå容äœã®çµã¿åãããäœãã®ã¯ãªããªã倧å€ã ãããéèšåºç 究ã§äœ¿ãããŠãã ã¯ãã¶ãã³-N-ãªãã·ãã¯çµ±å倱調çæ²»çè¬ã¯ãã¶ãã³ã®ä»£è¬ç£ç©ã§ãããæ¬åœã«è¬ç掻æ§ããªãã®ãã©ããã¯äžæãªç¹ãå€ããšèšãããŠããã
ã»ç¹å®ã®ç¥çµåè·¯ããç¹å®ã®æéã ããç¹å®ã®åŒ·ãã§å¶åŸ¡ã§ãããšããæè¡ãå®çŸã§ããã°ãç»æçãªæ²»çæ³ãšãªãã ãããäžæ¹ã§ã䟵襲æ§ã®é«ãå€ç§çæè¡ãAAVãã¯ã¿ãŒæäžãªã©æ£è ããã®è² æ ã¯å€§ããããã察象ãšãªãæ£è ããã¯éå®ããããããããªãã
ã»åããããªã¢ãããŒããè¡ã£ãŠãããã€ãªãã³ãã£ãŒã«Redpin Therapeuticsãããã
ããŒã¯ãŒãïŒ
ã»éºäŒåæ²»ç
ã»åæçç©åŠ
ã»ãã¶ã€ããŒå容äœ
ã»DREADDïŒdesigner receptors exclusively activated by designer drugsïŒ
ã»ç¥çµçŸæ£ïŒç¥çµå æ§çŒçããŠãããïŒ
å 責äºé ïŒ
æ£ç¢ºãªæ å ±æäŸãå¿ãããŠããŸãããæ¬å 容ã«åºã¥ããåŠäœãªãã¢ã¯ã·ã§ã³ã«å¯ŸããŠãã±ã³ã¯è²¬ä»»ããšããŸããããããããé¡ãããŸãã